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The Mission River is a river in Texas. It is formed by the confluence of Blanco and Medio creeks in central Refugio County (at 28°19' N, 97°19' W) and runs southeast, past Refugio, for twenty-four miles to its mouth on Mission Bay, an inlet of Copano Bay (at 28°10' N, 97°10' W). It traverses gently undulating coastal prairies surfaced by clay and loam and spotted by groves of hardwoods and pines. It is home to myriad waterfowl and native slough grasses.